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How does it work?

Zanidip tablets contain the active ingredient lercanidipine hydrochloride, which is a type of medicine called a calcium channel blocker. Lercanidipine is also available without a brand name, ie as the generic medicine. Lercanidipine works by slowing the movement of calcium through the muscle cells that are found in the walls of blood vessels. It does this by blocking 'calcium channels' in these muscle cells. Calcium is needed by muscle cells so that they can contract. Lercanidipine reduces the amount of calcium available to muscle cells and so makes them relax. Lercanidipine acts specifically on the muscle cells in the walls of arteries, causing them to relax. This allows the arteries in the body to widen. The relaxing and widening of the small arteries in the body decreases the resistance that the heart has to push against in order to pump the blood around the body. This reduces the pressure within the blood vessels. Lercanidipine can therefore be used to lower high blood pressure. Lercanidipine can also have a widening effect on the small arteries in the heart, which improves the supply of blood, and therefore the oxygen to the heart. This reduces the effort the heart has to make to pump blood around the body.

What is it used for?

• High blood pressure (hypertension).

Warning!

• Dizziness and weariness may occasionally occur during treatment with blood pressure lowering medicines. If you are affected, you should take extra care when driving or operating machinery.
• You should not drink grapefruit juice while you are taking this medicine, as it can increase the level of isradipine in your blood. This could increase its effect on your blood pressure and make you feel dizzy, and could also increase the risk of experiencing other side effects.

Use with caution in

• Elderly people.
• Chronic heart failure.
• Sick sinus syndrome, a problem common in the elderly, that affects the heart.
• Decreased kidney function.
• Decreased liver function.
• Narrowing of the main artery coming from the heart (aortic stenosis).

Not to be used in

• Allergy to other related calcium channel blockers (dihydropyridines), eg nifedipine, amlodipine.
• Children or adolescents under 18 years of age.
• Heart failure
• Angina that is increasing in severity, duration or frequency (unstable angina).
• People who are having a heart attack or who have had a heart attack in the last month.
• Failure of the heart to maintain adequate circulation of blood (cardiogenic shock).
• Pregnancy.
• Breastfeeding.
• Hereditary blood disorders called porphyrias.
• Zanidip tablets contain lactose and are not suitable for people with rare hereditary problems of galactose intolerance, Lapp lactose deficiency or glucose-galactose malabsorption.

This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately. Pregnancy and breastfeeding Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

• This medicine should not be used during pregnancy as it may be harmful to the unborn baby. Seek further medical advice from your doctor.
• This medicine may pass into breast milk in small amounts. The effect on a nursing infant is not known. For this reason, the manufacturer states that it should not be used during breastfeeding. Seek further medical advice from your doctor.

Label warnings

• Take this medication half to one hour before food.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.